Reproduction Abstracts

Background: The impact of androgens on myometrial contraction has received less scrutiny, compared to progesterone and estrogens. We sought to i) examine the effect of dihydrotestosterone (DHT; a non-aromatizable androgen) on stretch-induced contraction of human myometrium and ii) gain mechanistic insights by studying changes in intracellular calcium [Ca2+] and phosphorylation of myosin light chain (MLC).Methods: Myometrial strips were recover...